Beyond Filler: The Rise of Regenerative Skin Treatments with Salmon DNA
Beyond Filler: The Rise of Regenerative Skin Treatments with Salmon DNA
What Is Salmon DNA Skin Treatment and How Does It Differ from Traditional Fillers?
Regenerative skin therapy using salmon DNA (also known as PDRN, polynucleotides) is part of a newer wave in dermatology that focuses on cellular repair rather than just temporary volume. This article is about beyond filler: the rise of regenerative skin treatments with salmon DNA.
Unlike traditional dermal fillers, which “fill” by injecting substances (like hyaluronic acid) to add volume under the skin, salmon DNA treatments aim to stimulate your own skin cells to heal, regenerate, and rebuild collagen and elastin.
This means the improvements tend to happen gradually, more naturally, and often with better long‑term texture improvements rather than an immediate plump.
Salmon DNA in skincare refers specifically to polydeoxyribonucleotide (PDRN), fragments of DNA extracted from esperma de salmón (most commonly salmon trout or chum salmon). These DNA fragments are purified, sterilized, and processed so that they are safe and biocompatible.
Because salmon and human DNA sequences share enough similarities, the body can use the building blocks to aid repair without strong immune rejection. Popular brands you’ll see are Rejuran Healer, Ameela, Plinest, and Nucleofill.
These are often referred to as salmon DNA facials or PDRN skin boosters.
One of the key differences is that fillers typically provide immediate volume and plumpness, but may not significantly improve skin quality (texture, pore size, tone). Salmon DNA-based treatments promote both anti-aging and skin rejuvenation more holistically.
For individuals seeking a more natural and gradual improvement, with a reduced risk of overfilling, PDRN presents a compelling option.
Índice
How Does Salmon DNA Stimulate Skin Regeneration?
How Does It Trigger Collagen and Elastin Production?
How Does Deep Hydration Come from PDRN Skincare?
What Are the Anti‑Inflammatory Effects of Polynucleotide Injections for Skin?
How Does Salmon DNA Enhance Healing, Including for Acne Scars and Other Skin Damage?
How Is the Treatment Administered: Microneedling, Injectable Skin Boosters, and Topicals?
How Does Salmon DNA vs. Traditional Dermal Fillers Compare: Pros, Cons, and Use‑Cases?
What Are the Potential Risks, Side Effects, and Safety Considerations?
Who Is an Ideal Candidate for Salmon DNA Treatment (PDRN Skin Booster)?
Why Are Traditional Fillers No Longer the Only Option for Anti‑Aging?
What Is Regenerative Aesthetics, and Why Is It So Popular Now?
How Does the Concept of “Repair, Not Just Fill” Change the Beauty Industry?
How Does Salmon DNA Treatment Improve Skin Texture, Tone, and Hyperpigmentation?
Can This Treatment Help with Acne Scars, Dark Circles, and Hyperpigmentation?
Preguntas más frecuentes (FAQ)
Conclusión
Referencias
How Does Salmon DNA Stimulate Skin Regeneration?
At its core, PDRN works by supplying your skin with polynucleotide fragments that serve as raw materials in the repair process.
These fragments contribute to what’s known as the “salvage pathway” for DNA repair. In other words, when your skin cells need to repair themselves (after damage from sun, age, acne, etc.), PDRN gives them nucleotides/nucleosides to do so.
Another mechanism is via activation of adenosine A₂A receptors. Research shows that PDRN from salmon DNA binds to these receptors, which are involved in modulating inflammation, promoting tissue repair, and stimulating angiogenesis (the formation of new blood vessels) to increase nutrient flow and cell renewal.
Finally, the process encourages increased cellular turnover. That is, older and damaged cells are replaced more efficiently, skin barrier functions improve, and each cycle leaves skin smoother and healthier.
Over time, this adds up to better skin radiance, fewer fine lines, reduced hyperpigmentation, improved tone, and texture.
How Does It Trigger Collagen and Elastin Production?
Fibroblasts are the key players here. These cells in the dermis are responsible for producing collagen and elastin, two proteins essential for maintaining skin elasticity, firmness, and a youthful appearance.
Salmon DNA / PDRN treatments upregulate fibroblast activity. In vitro and in vivo studies have documented increased fibroblast proliferation, elevated expression of markers for collagen types (e.g., types I and III), and enhanced elastin repair.
Because PDRN promotes angiogenesis, the dermal environment becomes more supportive, better blood flow means more oxygen and nutrients are available to fibroblasts, which in turn support collagen/elastin synthesis, resulting in a healthier extracellular matrix (ECM).
Gradual visible results: over weeks to months, as new collagen and elastin mature, skin becomes firmer, wrinkles become less noticeable, and elasticity improves. The pace depends on baseline skin condition, treatment method, frequency, and lifestyle.
How Does Deep Hydration Come from PDRN Skincare?
Hydration is more than just applying water to the skin; it’s about enhancing the skin’s ability to retain moisture and maintain its barrier function.
Salmon DNA treatments help in several ways:
- They improve the extracellular matrix, which can hold moisture more effectively (the matrix is like a sponge: a better structure = better moisture retention).
- PDRN enhances the production of hyaluronic acid (naturally produced in the skin) by stimulating the cells that produce it, or at least improves the environment, allowing existing hydration levels to be maintained more effectively. Some studies mention improved skin elasticity and hydration as early visible benefits.
- Using a PDRN serum or skin booster helps plump the skin from within, leading to a visibly plumper, dewier appearance without relying solely on moisturizers.
Thus, deep hydration isn’t just topical, but structural.
What Are the Anti‑Inflammatory Effects of Polynucleotide Injections for Skin?
PDRN has been shown to reduce inflammation markers in skin.
Part of this is mediated through the adenosine A₂A receptor pathway, which modulates and suppresses the production of inflammatory cytokines.
Clinically, people report calming of red, irritated skin. This is especially helpful for those with acne‑prone, sensitive, or reactive skin.
The anti-inflammatory effect helps reduce irritation caused by environmental stress, treatments such as lasers, or other insults.
It also aids in the healing process (less inflammation speeds up healing).
With treatments such as acne scars and skin damage, PDRN helps by enhancing regeneration and dampening inflammatory damage that would otherwise prolong healing or exacerbate pigment or scarring.
How Does Salmon DNA Enhance Healing, Including for Acne Scars and Other Skin Damage?
Because salmon DNA/PDRN helps with cellular turnover, fibroblast regeneration, angiogenesis, and inflammation control, it accelerates tissue repair.
This is directly relevant to acne scars: when acne damages the skin, the healing process determines how well scars fade or flatten. With PDRN, that process is improved.
In addition, PDRN helps with post‑inflammatory hyperpigmentation (PIH) and uneven tone, often a consequence of acne or injury, by regulating melanogenesis, improving extracellular matrix, and reducing inflammation.
Other skin damage, such as photodamage from the sun, minor wounds, and so on, also benefits from PDRN, as it promotes angiogenesis and cell proliferation, allowing minor damage or UV damage to be repaired more efficiently, thereby reducing signs like fine lines, rough texture, and dullness.
How Is the Treatment Administered: Microneedling, Injectable Skin Boosters, and Topicals?
There are several delivery methods, each with its own pros & cons:
- Microneedling or mesotherapy: A PDRN (or salmon DNA serum) is applied topically or in infusions, using fine needles to create micro-injuries that help the product penetrate the dermis. Less invasive, with less downtime, and effective for improving texture, tone, and light wrinkles.
- Injectable skin boosters: More potent, using fine needle injections of polynucleotide gel or PDRN skin boosters directly into specific targeted areas. These are stronger, more durable results. Used for wrinkle reduction, skin rejuvenation treatments, acne scar correction, areas like cheeks, nasolabial folds, and under‑eye.
- Topical skincare: Serums, creams, masks with salmon DNA serum or PDRN content. These are less concentrated; effects are milder and more gradual. Ideal for those seeking a less invasive approach or for sensitive skin.
Depending on your goals, a provider might recommend a combination (e.g., microneedling with a PDRN serum, followed by injectable boosters for deeper wrinkles or scars).
How Does Salmon DNA vs. Traditional Dermal Fillers Compare: Pros, Cons, and Use‑Cases?
Pros of Salmon DNA / PDRN treatments:
- More natural, gradual improvements in skin quality (texture, tone, hydration, elasticity) in addition to volume where needed.
- Less risk of overfilling or unnatural results.
- Biocompatible and well-tolerated in many studies.
- It can address multiple skin issues (acne scars, wrinkles, dullness) simultaneously due to its regenerative effect.
Contras:
- Slower onset of visible results (you may need several sessions, weeks to months).
- Cost can accumulate due to the need for multiple treatments and maintenance.
- Not always as dramatic for volume loss as strong hyaluronic acid fillers. If you’re trying to fill deep hollows or profound wrinkles, fillers may be a more efficient option.
Use‑cases:
- When someone wants a more natural, rejuvenated look rather than volume.
- For mild to moderate wrinkles, early signs of aging, acne scars, and texture issues.
- For people with sensitive skin who prefer fewer foreign materials.
Traditional fillers still have a place: for instant volume, profound wrinkles, lips, cheeks, when volume is needed.
However, “repair, not just fill” treatments are gaining popularity for general skin health and aesthetic maintenance.
What Are the Potential Risks, Side Effects, and Safety Considerations?
Even though PDRN is generally well tolerated, there are potential risks and side effects:
- Temporary redness, swelling, itching, and bruising at the site of injection or microneedling.
- Mild irritation or breakouts, especially in acne‑prone skin.
- Flare‑ups in individuals with chronic inflammatory skin conditions.
- Allergic reactions: Since PDRN is derived from salmon (an animal source), individuals with fish or seafood allergies may be at risk. Even though it’s purified, this risk is not zero.
- There is a risk of infection if procedures are not performed in sterile medical settings.
There are also practical safety concerns:
- Ensuring the product is purified correctly and manufactured under reasonable quality control. Some treatments, especially in less regulated environments, may have poorly measured concentrations or impure content.
- Regulatory issues: In some countries, injectable PDRN may not be fully approved, while in others, topical forms are permitted. So legality and practitioner certification vary.
Thus, selecting a reputable clinic, conducting patch tests (if there is an allergy risk), and following after-care instructions are all important.
Who Is an Ideal Candidate for Salmon DNA Treatment (PDRN Skin Booster)?
People who tend to benefit most include:
- Those with mild to moderate signs of aging: fine lines, early wrinkles, and skin laxity.
- Individuals with dull, tired‑looking skin who want to regain radiance and texture, not just volume.
- For those with dehydrated skin who require deep hydration and barrier repair.
- People with acne scars or post‑inflammatory hyperpigmentation who want improved healing and regeneration.
- Those with uneven skin tone, rough texture, and large pores.
People who may no be ideal candidates include those with:
- Severe loss of volume (deep hollows) where fillers may be more effective.
- Fish allergies or strong sensitivity to animal‑derived components.
- Active infection or severe acne flare at the treatment site.
- Specific autoimmune or systemic diseases that affect healing (must be evaluated on a case-by-case basis).
Why Are Traditional Fillers No Longer the Only Option for Anti‑Aging?
Traditional fillers (like hyaluronic acid, calcium hydroxylapatite, etc.) have been mainstays because they deliver immediate volume, lifting, and contouring.
However, there are downsides: they may not improve skin quality, may shift over time, risk overuse, and sometimes yield unnatural results. Maintenance is frequent, costs can be high, and some patients dislike the “filled” aesthetic.
Regenerative options, such as salmon DNA/PDRN, bring about a shift: targeting the quality of skin (texture, elasticity, tone) rather than just volume. They work in conjunction with the body to facilitate healing and regeneration.
As demand for more natural, biocompatible, longer‑term aesthetic solutions increases, people are seeking treatments that accomplish more than filler alone. The perception is moving from “fixing wrinkles” to “repairing and maintaining youthful skin.”
Also, regulatory and safety awareness is increasing: people want fewer side effects and more sustainable results. This drives research and interest in treatments like PDRN vs fillers.
What Is Regenerative Aesthetics, and Why Is It So Popular Now?
Regenerative aesthetics refers to treatments and technologies that support the body’s natural healing, repair, and restoration processes rather than just masking signs of aging.
It includes treatments such as PDRN, PRP (platelet-rich plasma), stem cell-derived therapies, and exosomes, among others.
Why is it popular now?
- Increased research demonstrating safety and efficacy.
- Consumer demand for more “natural,” less invasive, less artificial treatments.
- Social media and celebrity influence (people sharing salmon DNA facials, etc.).
- Advances in biochemistry, extraction, and purification techniques have made PDRN more accessible and safer to use.
Additionally, with longer life expectancies, more people seek treatments that promote skin health over the course of decades, rather than just patching up their skin occasionally.
The cost over time of regenerative therapy may even out compared to repeated filler injections.
How Does the Concept of “Repair, Not Just Fill” Change the Beauty Industry?
This concept implies that treatments are not purely cosmetic in the sense of adding something external; instead, they activate internal processes of healing, regeneration, and maintenance.
The beauty industry is adapting:
- A greater focus on ingredients and treatments that support the skin barrier, DNA repair, and collagen remodeling, among others.
- Skincare and medical aesthetic providers are combining treatments (e.g., microneedling with PDRN, or PDRN with laser) rather than performing a single procedure.
- Marketing is shifting: people care more about long-term skin health, a natural glow, and sustainability, rather than extreme plumping.
Additionally, it alters regulations, product development, and patient expectations.
Patients increasingly ask, ‘What can I do to prevent damage?’
How can I regenerate?
Can I opt for less invasive treatments with longer-lasting benefits?
Salmon DNA/PDRN is at the intersection of these demands.
How Does Salmon DNA Treatment Improve Skin Texture, Tone, and Hyperpigmentation?
Salmon DNA improves texture and tone via multiple mechanisms:
- By increasing collagen and elastin, the skin becomes smoother, pores become less noticeable, and fine lines become less noticeable.
- By boosting cellular turnover and reducing inflammation, post‑inflammatory pigmentation and UV‑induced discoloration can fade more effectively. Some studies have shown that regulated melanogenesis (the production of pigment) occurs when PDRN is combined with antioxidant agents.
- Improved hydration and barrier function mean less dryness, less flakiness, and more even surface reflectance (skin looks more luminous).
Hyperpigmentation is helped because inflammation (which often triggers more melanin) is reduced, and repair is enhanced, so the skin can heal without leaving as much residual pigment.
Can This Treatment Help with Acne Scars, Dark Circles, and Hyperpigmentation?
Yes. There is growing evidence that PDRN / salmon DNA treatments can help significantly with acne scars and often dark circles (under‑eyes), though results vary.
Acne scars benefit because of enhanced collagen production, tissue regeneration, and faster healing. Specific “scar” versions of PDRN (higher-viscosity polynucleotide injectables) are used for treating deeper scars.
Dark circles are more challenging because they can be due to multiple causes (thin skin, pigmentation, vascular issues, fat loss, shadowing).
Some PDRN treatments (especially under‑eye injectables or boosters) help by improving skin thickness, stimulating collagen under the eye, and reducing pigmentation/inflammation. But results tend to be more modest and gradual.
In hyperpigmentation and PIH, PDRN again helps by controlling inflammation, enhancing repair, and promoting regenerative capacity.
It may be used in conjunction with brighteners (such as vitamina C and niacinamide) for a more effective result.
Frequently Asked Questions (FAQs) about Beyond Filler: The Rise of Regenerative Skin Treatments with Salmon DNA
Q1: Is the salmon DNA booster worth the hype?
Respuesta concisa: Yes, if your goal is gradual, natural skin regeneration rather than instant volume.
Respuesta detallada: The salmon DNA booster (PDRN skin booster) has been demonstrated in studies and clinical use to enhance skin texture, hydration, and elasticity, while also addressing fine lines and acne scars with relatively low risk.
If you value skin health, want more than just filling, and are okay with gradual improvements over weeks to months, many people find it’s worth it. But it may not replace fillers for all needs, especially for profound wrinkles or volume loss.
Q2: Does salmon DNA really work?
Respuesta concisa: The current research suggests yes, particularly for regeneration, healing, hydration, and mild to moderate anti‑aging effects.
Respuesta detallada: Multiple in vitro, in vivo, and clinical studies show that PDRN derived from salmon DNA promotes fibroblast activity, collagen and elastin production, reduces inflammation, angiogenesis, and improves skin repair.
While results vary depending on skin type, treatment method, and baseline skin condition, the evidence is strong that it has real benefits for skin rejuvenation.
Q3: Who should avoid salmon sperm skincare?
Respuesta concisa: People with fish or seafood allergies, active infections or skin disease, or certain immune‑compromised conditions should avoid or consult a physician first.
Respuesta detallada: Because PDRN is derived from salmon (an animal source), anyone with fish allergies should be cautious; even after purification, there’s a theoretical risk.
Additionally, individuals with active skin infections (such as untreated acne or open wounds), severe skin conditions (including certain types of eczema), or compromised immune systems should avoid injectables or invasive procedures until cleared.
Pregnant or breastfeeding individuals are advised to consult their doctor.
Q4: Is salmon DNA microneedling worth it?
Respuesta concisa: Yes, especially for improved texture, tone, and hydration, with less downtime compared to injections.
Respuesta detallada: Microneedling, combined with a salmon DNA serum or infusion, enables the PDRN to reach the dermis through microchannels, enhancing penetration, estimular la producción de colágeno, and promoting healing with minimal invasion.
It’s often less painful, has a shorter recovery time, and can be a good option for people seeking regenerative skin therapy without the need for injectables.
However, the effects may be less dramatic than direct injections for deep wrinkles or scars.
Q5: Does it truly offer deep, long‑lasting hydration?
Respuesta concisa: It offers better hydration than many surface treatments, with effects that last months, depending on maintenance.
Respuesta detallada: Because salmon DNA / PDRN improves skin structure, barrier function, and supports the skin’s ability to hold moisture (via improved ECM and fibroblast work), hydration tends to be more profound and more lasting than just applying moisturizers.
However, sustaining the effect depends on regular treatments, proper skincare, sun protection, and a healthy lifestyle.
Q6: How effective is it for reducing fine lines and wrinkles?
Respuesta concisa: Moderately to very effective for mild to moderate fine lines; less so for profound wrinkles unless combined with other treatments.
Respuesta detallada: For fine lines, especially around the eyes or surcos nasogenianos, salmon DNA treatments have shown visible improvement over a few sessions. The stimulation of collagen and elastin helps tighten the skin and smooth superficial lines.
Deep wrinkles may require stronger modalities (fillers, more invasive procedures), but PDRN can complement them by improving surrounding skin and slowing further degeneration.
Q7: Can it be used to treat delicate areas like the under‑eye?
Respuesta concisa: Yes, when done carefully by a skilled practitioner.
Respuesta detallada: Under‑eye skin is thin and delicate, which means risks of swelling, bruising, or fluid retention are slightly higher.
However, injectable PDRN boosters, explicitly designed for the eye zones (often labeled PDRN I or similar), are used under the eyes to improve dark circles, thin skin, and fine lines by increasing collagen, enhancing skin thickness, and reducing pigmentation or vascular shadows.
Topical serums with PDRN are also gentler alternatives for this area.
Q8: Does it have anti‑inflammatory benefits for sensitive skin?
Respuesta concisa: Yes, one of its well‑documented benefits is calming inflammation and helping heal irritated or reactive skin.
Respuesta detallada: PDRN acts via adenosine A₂A receptors to reduce inflammatory cytokines.
Clinically, people with sensitive or acne-prone skin report reduced redness, irritation, and improved recovery after exposure to environmental or procedural stress. But sensitivity varies; patch testing or starting with topical forms may be wise.
Q9: Can you use Salmon DNA serum with microneedling?
Respuesta concisa: Yes, this combination is common and can enhance results.
Respuesta detallada: Microneedling creates micro‑channels that allow a salmon DNA serum (or PDRN topical) to penetrate more deeply, increasing efficacy. Many clinics pair the two: microneedling + PDRN skin booster or serum infusion.
However, hygiene is crucial; the risk of infection is higher if equipment isn’t sterile or post‑care is neglected.
Q10: What are the potential side effects, and is there any downtime associated with this treatment?
Respuesta concisa: Mild redness, swelling, bruising, or tiny bumps are standard; downtime is minimal, often 24‑72 hours.
Respuesta detallada: After tratamientos inyectables, some swelling, redness, tiny bumps, or slight bruising can occur, usually resolving in 1‑3 days. For microneedling or topical applications, irritation or peeling is possible.
There is little to no extended downtime; most people return to daily activity quickly, though avoiding harsh sunlight, heavy makeup, etc., for 24‑48 hours is advised.
Q11: Who should avoid this type of treatment?
Respuesta concisa: People with fish/seafood allergy, active skin infections, compromised immune system, or pregnant/breastfeeding without medical clearance.
Respuesta detallada: As noted, the risk of allergic reaction due to animal-source DNA indicates that fish/seafood allergies are a significant concern.
Additionally, anyone with skin infections (viral, fungal, or bacterial), individuals with autoimmune conditions that can flare, or those taking certain medications (e.g., strong immunosuppressants) should exercise caution.
Always have a medical history review by a qualified provider. The regulatory and legal status of injectable salmon DNA in one’s country also matters.
Q12: Is the treatment painful, and what can you expect during a session?
Respuesta concisa: Slight discomfort is typical, but pain is manageable using numbing and technique; sessions last 30‑60 minutes, depending on the area.
Respuesta detallada: For injectable PDRN, there is some stinging or pinching when needles are used. Many clinics use a topical anesthetic or cooling to reduce discomfort.
Microneedling can cause some discomfort, but it is milder. Overall, most people find it tolerable and short in duration.
After the session, mild soreness or tightness is common, but it typically subsides within one to two days.
Q13: How do you maintain the results and prolong the benefits?
Respuesta concisa: Follow up with regular maintenance sessions, practice good skincare (including sun protection and antioxidants), adopt a healthy lifestyle, and avoid excessive sun damage.
Respuesta detallada: After your initial course (often 3‑4 sessions spaced a few weeks apart), maintenance every 4‑6 or 6‑12 months helps preserve results.
Using PDRN serums or topicals, protecting the skin from UV rays, getting enough sleep, maintaining a healthy diet, and avoiding smoking all support collagen maintenance.
Also, pairing with complementary treatments (lasers, light therapy) when needed can help.
Q14: Is salmon DNA skincare a legitimate product or just a fad?
Respuesta concisa: It appears to be legitimate based on growing scientific evidence, though long‑term studies are still fewer than for some other treatments.
Respuesta detallada: Research reviews in recent years have consistently reported that PDRN (salmon DNA) has real biological activity (cell repair, collagen synthesis, anti‑inflammation, etc.). It’s been used in dermatology and reconstructive contexts.
The hype around cosmetic enhancements has amplified interest, but while it isn’t a miraculous cure‑all, it is more than just marketing. As always, results depend on application, product quality, provider skill, and consistency.
Q15: Is PDRN suitable for treating dark circles under the eyes?
Respuesta concisa: Yes, for some types of dark circles (especially those due to thin skin, pigmentation, or vascular issues), PDRN treatments can help.
Respuesta detallada: Under‑eye dark circles are multifactorial. The skin under the eyes is fragile, so collagen loss, pigment deposition, and vascular shadowing can all contribute to the appearance.
PDRN skin boosters or injectable polynucleotides targeted to the under-eye area can help thicken the skin, improve circulation, reduce pigmentation/inflammation, and thus reduce the appearance of dark circles.
The results are subtler and slower than treatments solely targeting pigment, but many patients report noticeable improvement.
Conclusion: Beyond Filler: The Rise of Regenerative Skin Treatments with Salmon DNA
What if the secret to glowing, youthful skin wasn’t in covering up the signs of aging, but healing them from the inside out?
That’s precisely what Salmon DNA skin treatments promise, and more importantly, deliver. Unlike fillers that fade and creams that merely sit on the surface, PDRN goes deep, encouraging your skin to rebuild, restore, and renew itself at the cellular level.
It’s not just skincare. It’s skin repair.
This isn’t a passing trend or a beauty buzzword. It’s regenerative science meeting aesthetics.
Whether you’re battling fine lines, acne scars, dullness, or dark circles, Salmon DNA offers a new beginning for your skin, a gentler, safer, and more natural path to transformation.
It nurtures rather than forces change, making it ideal for anyone tired of temporary fixes and longing for lasting vitality.
Choosing this treatment is more than a cosmetic decision; it’s a declaration that you believe your skin deserves more than a quick fix. It deserves regeneration.
It deserves care.
It deserves the strength of something as profound and powerful as life’s very blueprint, DNA.
So if you’ve ever looked in the mirror and wished your skin could feel alive again, this may be your chance to make that wish come true, finally.
Your skin knows how to heal; it just needs the proper signal. Let salmon DNA be that signal.
We have covered everything about Beyond Filler: the rise of regenerative skin treatments with salmon DNA.
Referencias
Clínica de terapia intravenosa de West Palm Beach
Actividad farmacológica y uso clínico de PDRN
Fuente: F. Squadrito et al., published via PMC / National Institutes of Health.
Between rat models and clinical trials, this article describes how PDRN (salmon DNA fragments) exhibits tissue-repairing, anti-ischemic, and anti-inflammatory effects, substantially improving wound healing in diabetic foot ulcers with excellent safety.
Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness
Fuente: KWA Lee et al., MDPI / International Journal of Molecular Sciences (2024).
This review examines the evidence for PDRN/polynucleotide applications in aesthetic medicine, including skin texture, wrinkle depth, elasticity, side-effect profiles, and applications such as dark circles and acne scars.
Polydeoxyribonucleotide: A Promising Skin Anti‑Aging Agent
Fuente: A. Khan et al., via ScienceDirect.
This study reviews the anti-aging properties of PDRN in the cosmetic industry, examining its influence on collagen, elastin, and clinical outcomes related to wrinkle reduction.
Fuente: Chang Sik Pak et al., Journal of Korean Medical Science.
In this clinical trial + animal study, purified polynucleotide filler (Rejuran®) was compared to HA filler in treating crow’s feet; it showed improvements in wrinkle depth, elasticity, and texture; the PN filler was non‑inferior to the HA filler in many measures and had good safety.
Analysis of Skin Regeneration and Barrier‑Improvement by Panax PDRN vs. Salmon PDRN
Fuente: KS Lee et al., via PMC.
This work examines the comparison of PDRN extracted from Panax ginseng with that from salmon (testes) in terms of skin cell regeneration and skin barrier improvement. Plant-derived PDRN can mimic many of the repair effects found with salmon DNA PDRN, potentially serving as an alternative source.
The Role of Salmon DNA in Skin Regeneration and Anti‑Aging
Fuente: Anita Camilia et al., MEDINFTech.
A recent narrative review (2025) summarizes studies from ~2016 to 2023, highlighting the mechanisms of action (adenosine A2A receptor activation, angiogenesis, and cell proliferation), as well as practical effects such as improved texture, reduced wrinkles, and pore size, with high patient satisfaction.
Recent advances in polydeoxyribonucleotide extraction, purification, and clinical translation
Fuente: TH Nguyen et al., ScienceDirect (2024).
Focuses on the technical side: how PDRN is extracted & purified, optimizing molecular weight, safety / regulatory aspects, and early clinical translation for skin graft donor sites & applications in skin regeneration.
A New Concept of Regenerative Filler (same as item 4, but emphasizing the ‘Regenerative Filler’ framing)
Fuente: CS Pak et al., PMC (same group as #4).
See #4 for a summary; this article describes the same clinical trial but provides a comparison in terms of regenerative filler versus traditional approaches.
Fuente: SM Akaberi et al., Journal of Skin & Stem Cell (2025).
A more recent review expands the applications of PDRN, not only for anti-aging but also for acne scar treatment, hair regeneration, and melanogenesis (pigmentation), with data on molecular mechanisms (VEGF, purinergic receptor activation) and clinical outcomes.
Treatments of Infra‑Orbital Dark Circles by Various Etiologies
Fuente: KY Park et al., Annals of Dermatology.
This article is a review of the medical literature and clinical experience regarding dark circles (under-eye): causes (pigmentation, vascular, and structural), and treatment options. While it does not focus exclusively on PDRN, it provides context for how treatments like polynucleotide injections might fit into the dark circle therapeutic regimen.